Description

1-Bromo-2-Fluoro-5-Nitro-4-Trifluoromethyl-Benzene is a high-purity, multi-functional halogenated aromatic building block. This compound is valued for its unique combination of electron-withdrawing groups, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for specialty polymers.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl structures.
• Fluorine Chemistry Research: An important compound for studying the effects of multiple fluorine atoms on aromatic system reactivity and physical properties.
• Ligand and Catalyst Development: Used to synthesize sophisticated ligands for asymmetric catalysis or functionalized surfaces in heterogeneous catalysis.

Basic Information

Product Name	1-Bromo-2-Fluoro-5-Nitro-4-Trifluoromethyl-Benzene
CAS No.	1421599-50-9
Molecular Formula	C7H2BrF4NO2
Molecular Weight	287.99 g/mol
Synonyms	2-Bromo-1-Fluoro-4-Nitro-5-(Trifluoromethyl)benzene; 4-Bromo-3-Fluoro-6-Nitrobenzotrifluoride; 5-Bromo-4-Fluoro-2-Nitrobenzotrifluoride; 2-Fluoro-5-Nitro-4-Trifluoromethyl Bromobenzene; Benzene, 1-bromo-2-fluoro-5-nitro-4-(trifluoromethyl)-; NSC 876963
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to cGMP principles for manufacturing and quality management where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.