Description

1-Bromo-2,4-difluoro-3-nitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in cross-coupling reactions, nucleophilic aromatic substitution, and as a precursor to functionalized anilines.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed couplings to introduce the difluoronitrophenyl moiety into complex architectures.
• Nucleophilic Aromatic Substitution (SNAr): The activated nitro and halogen groups facilitate displacement with various nucleophiles, such as amines and alkoxides, to create diverse chemical libraries.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Bromo-2,4-difluoro-3-nitrobenzene
CAS No.	1420800-30-1
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	2,4-Difluoro-3-nitro-1-bromobenzene; 3-Nitro-2,4-difluorobromobenzene; 1-Bromo-2,4-difluoro-3-nitro-benzene; Benzene, 1-bromo-2,4-difluoro-3-nitro-; 1420800-30-1 (CAS); 2,4-Difluoro-1-bromo-3-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4-difluoro-3-nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.