Description

2-(Difluoromethoxy)-1,3-Difluoro-5-Nitrobenzene is a high-value fluorinated aromatic building block, distinguished by its unique difluoromethoxy and nitro substituents. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is required to modulate biological activity, stability, and lipophilicity. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where fluorination improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic aromatic substitutions, and other transformations to construct complex fluorinated architectures.

Basic Information

Product Name	2-(Difluoromethoxy)-1,3-Difluoro-5-Nitrobenzene
CAS No.	1417568-83-2
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	1,3-Difluoro-5-nitro-2-(difluoromethoxy)benzene; Benzene, 2-(difluoromethoxy)-1,3-difluoro-5-nitro-; 2-(Difluoromethoxy)-1,3-difluoro-5-nitrobenzene; 5-Nitro-1,3-difluoro-2-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-1,3-Difluoro-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.