Description

3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique cyclobutane scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its constrained cyclobutane ring and trifluoromethyl group.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Proteolysis Targeting Chimera (PROTAC) Development: The amine and alcohol functionalities make it a valuable linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with enhanced metabolic stability.

Basic Information

Product Name	3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride
CAS No.	1408075-12-6
Molecular Formula	C5H9F3NO•HCl
Molecular Weight	207.59 g/mol (Free base: 171.13 g/mol)
Synonyms	1-(Trifluoromethyl)-3-aminocyclobutan-1-ol hydrochloride; 3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride; 1-Cyclobutanol, 3-amino-1-(trifluoromethyl)-, hydrochloride; 3-Amino-1-trifluoromethylcyclobutan-1-ol HCl; (3-Amino-1-(trifluoromethyl)cyclobutyl) hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.