Description

8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-Ol is a high-purity, advanced pharmaceutical intermediate featuring a complex bridged bicyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those with tropane alkaloid-like structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for neurological and psychiatric disorders.
• API Development: Serves as a precursor in the multi-step synthesis of potential new chemical entities (NCEs) for clinical trials.
• Chemical Biology Probes: Utilized in the development of labeled compounds for studying biological pathways and receptor binding.
• Asymmetric Synthesis: Employed as a chiral scaffold for creating enantiomerically pure compounds due to its rigid, three-dimensional structure.

Basic Information

Product Name	8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-Ol
CAS No.	1404196-40-2
Molecular Formula	C12H20FNO3
Molecular Weight	245.29 g/mol
Synonyms	tert-Butyl 2-fluoro-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate; 2-Fluoro-8-azabicyclo[3.2.1]octan-3-ol, 8-(1,1-dimethylethyl) ester; 8-Boc-2-fluoro-8-azabicyclo[3.2.1]octan-3-ol; 8-(tert-Butoxycarbonyl)-2-fluoro-8-azabicyclo[3.2.1]octan-3-ol; 2-Fluoro-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; Bicyclo[3.2.1]octane-8-carboxylic acid, 2-fluoro-3-hydroxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.