Description

(3,4)-trans-1-(Benzyloxycarbonyl)-3-Fluoropiperidine-4-Carboxylic Acid CAS NO 1404196-36-6 is a high-purity, fluorinated piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Building block for novel pesticides and herbicides, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Peptidomimetics & PROTACs: Used in the synthesis of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its rigid, functionalized piperidine core.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration by introducing fluorine and carboxylic acid functionalities at specific positions on the piperidine ring.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of candidate drugs.
• Academic & Institutional Research: Used in universities and research institutes for methodological development in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	(3,4)-trans-1-(Benzyloxycarbonyl)-3-Fluoropiperidine-4-Carboxylic Acid
CAS No.	1404196-36-6
Molecular Formula	C14H16FNO4
Molecular Weight	281.28 g/mol
Synonyms	1-CBZ-3-Fluoro-4-piperidinecarboxylic Acid, trans-; (3R,4R)-1-[(Benzyloxy)carbonyl]-3-fluoropiperidine-4-carboxylic Acid; (3,4-trans)-1-(Benzyloxycarbonyl)-3-fluoropiperidine-4-carboxylic Acid; 3-Fluoro-1-CBZ-piperidine-4-carboxylic Acid; 1-N-CBZ-3-fluoroisonipecotic Acid; Z-3-Fluoro-4-piperidinecarboxylic Acid; 3-Fluoro-1-[(phenylmethoxy)carbonyl]-4-piperidinecarboxylic Acid; 1404196-36-6
EINECS	Contact for details

Quality Control

Our (3,4)-trans-1-(Benzyloxycarbonyl)-3-Fluoropiperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent industry standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.