Description

1-Fluoro-4-Nitro-2-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique combination of electron-withdrawing groups, which make it a critical intermediate in the development of pharmaceuticals and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoromethoxy and nitro groups impart specific biological activity.
• Material Science Research: Serves as a precursor for developing novel fluorinated polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it a suitable candidate for substitution reactions with various nucleophiles.
• Dye and Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	1-Fluoro-4-Nitro-2-(Trifluoromethoxy)Benzene
CAS No.	1404194-97-3
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	4-Nitro-1-fluoro-2-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)-1-fluoro-4-nitrobenzene; 1-Fluoro-2-(trifluoromethoxy)-4-nitrobenzene; 4-Fluoro-3-nitrobenzotrifluoride, Trifluoromethoxy derivative; NSC 876963; Benzene, 1-fluoro-4-nitro-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-Nitro-2-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.