Description

1-Fluoro-2-Nitro-3-(Trifluoromethoxy)Benzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring fluorine, nitro, and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific electronic and steric properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials that benefit from its electron-withdrawing characteristics.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of reactive halogen and nitro groups.
• Chemical Derivatization: The nitro group provides a versatile handle for reduction to amines or further functionalization, enabling the creation of diverse chemical libraries.

Basic Information

Product Name	1-Fluoro-2-Nitro-3-(Trifluoromethoxy)Benzene
CAS No.	1404193-85-6
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	2-Fluoro-1-Nitro-3-(Trifluoromethoxy)Benzene; 3-(Trifluoromethoxy)-2-fluoro-1-nitrobenzene; 1-Fluoro-2-nitro-3-(trifluoromethoxy)benzene; Benzene, 1-fluoro-2-nitro-3-(trifluoromethoxy)-; 2-Fluoro-3-(trifluoromethoxy)nitrobenzene; 2-Fluoro-α,α,α-trifluoro-3-nitrophenyl methyl ether
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Nitro-3-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.