Description

Ethyl 1-(Boc-Amino)-3-Fluorocyclobutanecarboxylate is a high-value, fluorinated cyclobutane derivative serving as a critical building block in modern organic synthesis. This compound matters for its unique structural features, combining a protected amine (Boc) and a fluorine atom on a strained cyclobutane ring, enabling precise molecular construction. Pharmaceutical and agrochemical researchers need it for developing novel active ingredients, particularly in medicinal chemistry for creating constrained analogs and probing structure-activity relationships. Its application extends to advanced material science for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in SAR (Structure-Activity Relationship) studies to introduce conformational restraint and modulate physicochemical properties like metabolic stability and membrane permeability.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Peptidomimetics: Core component in the synthesis of peptide mimics where the fluorocyclobutane scaffold replaces traditional amino acid backbones.
• Material Science Precursor: Intermediate for synthesizing fluorinated polymers and advanced materials with specific thermal, chemical, or surface properties.
• Chemical Biology Probes: Used to create labeled compounds and probes for studying biological mechanisms and enzyme functions.

Basic Information

Product Name	Ethyl 1-(Boc-Amino)-3-Fluorocyclobutanecarboxylate
CAS No.	1403766-93-7
Molecular Formula	C₁₂H₂₀FNO₄
Molecular Weight	261.29 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]-3-fluorocyclobutanecarboxylic Acid Ethyl Ester; Ethyl 1-[(tert-Butoxycarbonyl)amino]-3-fluorocyclobutanecarboxylate; 3-Fluoro-1-((tert-butoxycarbonyl)amino)cyclobutanecarboxylic acid ethyl ester; Boc-3-fluoro-cyclobutanamine-1-carboxylic acid ethyl ester; 1-N-Boc-amino-3-fluorocyclobutanecarboxylic acid ethyl ester; Ethyl 1-(tert-butoxycarbonylamino)-3-fluorocyclobutanecarboxylate; 1-(Boc-Amino)-3-fluorocyclobutanecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 1-(Boc-Amino)-3-Fluorocyclobutanecarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). Our rigorous quality testing includes identity confirmation, purity assay, and impurity profiling to meet the exacting standards of pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.