Description

1-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylic Acid CAS NO 1402664-77-0 is a high-value trifluoromethylated pyrazole derivative, a versatile and critical building block in modern synthetic chemistry. Its core value lies in the unique combination of the pyrazole heterocycle and the metabolically stable trifluoromethyl group, which is essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by advanced material scientists.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylpyrazole moiety enhances bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional organic materials, such as organic semiconductors or metal-organic frameworks (MOFs), due to its ability to influence electronic properties.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylic Acid
CAS No.	1402664-77-0
Molecular Formula	C5H3F3N2O2
Molecular Weight	180.09 g/mol
Synonyms	1-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid; 4-Pyrazolecarboxylic acid, 1-(trifluoromethyl)-1H-; 1H-Pyrazole-4-carboxylic acid, 1-(trifluoromethyl)-; 1-Trifluoromethyl-1H-pyrazole-4-carboxylic acid; 1-(Trifluoromethyl)-4-carboxypyrazole; TFMPA; 1-CF3-1H-Pyrazole-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.