Description

4,4-Difluoropiperidine-2-Carboxylic Acid is a high-value, fluorinated piperidine derivative serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring two fluorine atoms on the piperidine ring, makes it an essential intermediate for introducing conformational rigidity and modulating physicochemical properties in target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the difluoropiperidine moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioisosteres: The carboxylic acid functionality allows for incorporation into peptide backbones, acting as a proline or pipecolic acid bioisostere to improve metabolic stability and binding affinity.
• Material Science: Potential building block for specialty polymers and advanced materials requiring fluorinated components for specific performance characteristics.

Basic Information

Product Name	4,4-Difluoropiperidine-2-Carboxylic Acid
CAS No.	1402664-50-9
Molecular Formula	C6H9F2NO2
Molecular Weight	165.14 g/mol
Synonyms	2-Carboxy-4,4-difluoropiperidine; 4,4-Difluoro-2-piperidinecarboxylic acid; 4,4-Difluoropiperidine-2-carboxylic acid; 4,4-Difluoropipecolic acid; (4,4-Difluoropiperidin-2-yl)carboxylic acid; 2-Piperidinecarboxylic acid, 4,4-difluoro-; 1402664-50-9
EINECS	Contact for details

Quality Control

Our 4,4-Difluoropiperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and process development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.