Description

Colby Trifluoromethylation Reagent CAS NO 1400691-55-5 is a specialized organofluorine compound designed for the efficient introduction of the trifluoromethyl (CF3) group into organic molecules. This reagent is critical for medicinal chemistry and advanced materials science, where the CF3 group is a key structural motif known to enhance metabolic stability, lipophilicity, and bioavailability. It is an essential tool for researchers and process chemists in pharmaceutical R&D, agrochemical development, and the synthesis of functional materials.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating drug candidates with improved pharmacokinetic properties.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides with enhanced activity and environmental profile.
• Medicinal Chemistry & Lead Optimization: Enables late-stage trifluoromethylation to fine-tune the properties of bioactive molecules.
• Functional Material Production: Incorporation into organic semiconductors, liquid crystals, and polymers to modify electronic and physical characteristics.
• R&D and Process Chemistry: A versatile reagent for method development and scale-up in academic and industrial laboratories.
• Radiochemistry & Tracer Synthesis: Potential use in the preparation of fluorine-18 labeled compounds for Positron Emission Tomography (PET) imaging.

Basic Information

Item	Detail
Product Name	Colby Trifluoromethylation Reagent
CAS No.	1400691-55-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Colby Reagent; Trifluoromethylation Reagent Colby; 1,1,1-Trifluoro-N-phenylmethanesulfonamide; N-Phenyl-1,1,1-trifluoromethanesulfonamide; Phenyl trifluoromethyl sulfonamide; (Trifluoromethylsulfonyl)aniline; N-(Trifluoromethylsulfonyl)aniline; CAS 1400691-55-5
EINECS	Contact for details

Quality Control

Our Colby Trifluoromethylation Reagent is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.