Description

4-Amino-5-Fluoro-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic nitrile building block distinguished by its unique trifluoromethyl and fluorine substituents. This compound matters for its critical role in modern synthetic chemistry, enabling the introduction of fluorine atoms and nitrile groups to enhance the metabolic stability, lipophilicity, and binding affinity of target molecules. Pharmaceutical and agrochemical R&D teams need this advanced intermediate for the development of novel active ingredients, particularly in the creation of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially kinase inhibitors and anticancer agents.
• Agrochemical Synthesis: Used in the design and production of advanced pesticides and herbicides, where the fluorine and trifluoromethyl groups improve biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional materials, including liquid crystals and organic semiconductors.
• Fluorinated Building Block: Essential for medicinal chemistry programs focused on introducing fluorine atoms to modulate the pharmacokinetic properties of lead compounds.
• Chemical Synthesis: Employed in cross-coupling reactions and other transformations to construct complex, fluorinated aromatic systems.

Basic Information

Product Name	4-Amino-5-Fluoro-2-(Trifluoromethyl)Benzonitrile
CAS No.	1398046-66-6
Molecular Formula	C8H4F4N2
Molecular Weight	204.13 g/mol
Synonyms	2-Cyano-4-fluoro-5-amino-α,α,α-trifluorotoluene; 5-Fluoro-4-amino-2-(trifluoromethyl)benzonitrile; 4-Amino-5-fluoro-α,α,α-trifluoro-o-tolunitrile; 2-(Trifluoromethyl)-4-amino-5-fluorobenzonitrile; 5-Fluoro-2-(trifluoromethyl)-1,4-benzenediamine carbonitrile; 4-Fluoro-5-amino-2-(trifluoromethyl)benzonitrile; 1398046-66-6; 4-Amino-5-fluoro-2-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Fluoro-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.