Description

(6,6-Difluorobicyclo[3.1.0]hexan-3-yl)methanol CAS NO 1393553-93-9 is a high-value, fluorinated bicyclic building block of significant interest in advanced organic synthesis. Its unique strained-ring structure, functionalized with both a fluorinated core and a primary alcohol, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated motifs that can dramatically alter a molecule's metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the difluorinated bicyclo[3.1.0]hexane scaffold can impart improved environmental stability and pest selectivity.
• Fluorine Chemistry & Material Science: Serves as a specialized precursor for synthesizing fluorinated polymers, liquid crystals, or electronic materials with tailored properties like thermal stability and dielectric constant.
• Asymmetric Synthesis & Catalysis: The chiral, strained structure makes it a valuable substrate for developing new catalytic methodologies and creating chiral ligands or catalysts.
• Chemical Biology Probes: Utilized in the design of molecular probes and bio-conjugates to study biological processes, leveraging fluorine as a tag for 19F NMR spectroscopy.

Basic Information

Product Name	(6,6-Difluorobicyclo[3.1.0]hexan-3-yl)methanol
CAS No.	1393553-93-9
Molecular Formula	C8H12F2O
Molecular Weight	162.18 g/mol
Synonyms	(6,6-Difluorobicyclo[3.1.0]hexan-3-yl)methanol; 3-(Hydroxymethyl)-6,6-difluorobicyclo[3.1.0]hexane; 6,6-Difluorobicyclo[3.1.0]hexane-3-methanol; (6,6-Difluoro-3-bicyclo[3.1.0]hexanyl)methanol; Difluorinated Norbornane Methanol Derivative
EINECS	Contact for details

Quality Control

Every batch of (6,6-Difluorobicyclo[3.1.0]hexan-3-yl)methanol is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity confirmation (IR, NMR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.