Description

2-Bromo-6-(Trifluoromethoxy)Benzyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive benzyl chloride and bromo-trifluoromethoxy substitution pattern. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the stability and bioactivity imparted by the trifluoromethoxy and bromine groups.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals where the unique halogenated aromatic structure modifies physical properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological mechanisms and target engagement.

Basic Information

Product Name	2-Bromo-6-(Trifluoromethoxy)Benzyl Chloride
CAS No.	1393442-62-0
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	1-(Bromomethyl)-2-(trifluoromethoxy)-3-chlorobenzene; (2-Bromo-6-(trifluoromethoxy)phenyl)methyl chloride; α-Chloro-2-bromo-α-(trifluoromethoxy)toluene; 2-Bromo-α-chloro-6-(trifluoromethoxy)toluene; Benzene, 1-(bromomethyl)-2-(trifluoromethoxy)-3-chloro-; 3-Bromo-α-chloro-2-(trifluoromethoxy)toluene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-(Trifluoromethoxy)Benzyl Chloride is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain purity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.