Description

4-[4-(Trifluoromethyl)Phenyl]Methyloxane-4-Carbonitrile is a high-value, advanced pharmaceutical intermediate featuring a unique oxane ring system substituted with a trifluoromethylphenyl group and a nitrile functionality. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and metabolic disorders. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Agrochemical Development: Serves as a precursor for developing advanced crop protection agents with improved efficacy.
• Ligand and Catalyst Synthesis: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Potential monomer or additive for creating specialty polymers with unique thermal or optical properties.

Basic Information

Product Name	4-[4-(Trifluoromethyl)Phenyl]Methyloxane-4-Carbonitrile
CAS No.	1393330-51-2
Molecular Formula	C14H14F3NO
Molecular Weight	269.26 g/mol
Synonyms	4-((4-(Trifluoromethyl)phenyl)methyl)oxane-4-carbonitrile; Tetrahydro-4-[[4-(trifluoromethyl)phenyl]methyl]-2H-pyran-4-carbonitrile; 4-[[4-(Trifluoromethyl)phenyl]methyl]tetrahydro-2H-pyran-4-carbonitrile; 4-(4-(Trifluoromethyl)benzyl)tetrahydro-2H-pyran-4-carbonitrile; Oxane-4-carbonitrile, 4-[[4-(trifluoromethyl)phenyl]methyl]-
EINECS	Contact for details

Quality Control

Our 4-[4-(Trifluoromethyl)Phenyl]Methyloxane-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.