Description

1,3-Difluoro-2-Methoxy-4-Nitrobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring fluorine atoms and a nitro group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and pigments, leveraging the nitro group for color development and the fluorine atoms for stability.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of halogen atoms ortho and para to activating groups.
• Nucleophilic Aromatic Substitution: The fluorine atoms, activated by the ortho-nitro and methoxy groups, are highly reactive sites for nucleophilic substitution, enabling efficient introduction of diverse functionalities.

Basic Information

Product Name	1,3-Difluoro-2-Methoxy-4-Nitrobenzene
CAS No.	1393179-73-1
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2-Methoxy-1,3-difluoro-4-nitrobenzene; 4-Nitro-2-methoxy-1,3-difluorobenzene; 1,3-Difluoro-2-methoxy-4-nitro-benzene; Benzene, 1,3-difluoro-2-methoxy-4-nitro-; 2-Methoxy-1,3-difluoro-4-nitro-benzene; 1393179-73-1; MFCD31812842
EINECS	Contact for details

Quality Control

Every batch of 1,3-Difluoro-2-Methoxy-4-Nitrobenzene is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical synthesis steps. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.