Description

R-Doxylamine is a high-purity enantiomer of the antihistamine doxylamine, specifically the (R)-enantiomer. This compound is of significant interest in pharmaceutical research and development for its stereospecific biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of chiral active pharmaceutical ingredients (APIs), method development for enantiomeric separation, and pharmacological studies. The product is supplied under stringent quality control to ensure reliability for critical applications.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used as a certified standard for method development and validation in chiral HPLC and other analytical techniques.
• Pharmacological Research: Employed in preclinical studies to investigate the stereospecific effects, metabolism, and receptor binding profiles of antihistamines.
• Process Chemistry & Development: Serves as a starting material or intermediate in optimizing asymmetric synthesis routes and scaling up production.
• Quality Control Laboratories: Used for system suitability testing and as a comparator in identity and purity tests for doxylamine-based products.

Basic Information

Product Name	R-Doxylamine
CAS No.	1391849-33-4
Molecular Formula	C17H22N2O
Molecular Weight	270.37 g/mol
Synonyms	(R)-Doxylamine; (R)-2-[1-Phenyl-1-(2-pyridyl)ethoxy]-N,N-dimethylethanamine; (R)-N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine; Doxylamine (R-enantiomer); (R)-Doxylamine Succinate (salt form); UNII-95I74V6J8Q (for succinate); (R)-Histadoxylamine; (R)-Mereprime
EINECS	Contact for details

Quality Control

Our R-Doxylamine CAS NO 1391849-33-4 is manufactured under a quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for key parameters such as assay, chiral purity, and related substances. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.