Description

L-2-(o-Bromo-p-Fluorophenyl)Glycine Hydrochloride is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This chiral building block is critical for the synthesis of complex molecules, offering precise structural control for medicinal chemists. It is primarily utilized in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents, serving the needs of pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetics Development: Used to incorporate modified phenylglycine residues into peptide backbones to enhance stability, bioavailability, and receptor binding affinity.
• Protease Inhibitor Synthesis: Serves as a crucial component in the design and construction of inhibitors for various enzymatic targets.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying biological pathways and protein interactions.
• Asymmetric Synthesis: Acts as a valuable starting material or auxiliary in stereoselective chemical transformations to create enantiomerically pure compounds.
• API Process Development: Used in scale-up and optimization studies for the commercial manufacturing route of advanced pharmaceutical ingredients.

Basic Information

Product Name	L-2-(o-Bromo-p-Fluorophenyl)Glycine Hydrochloride
CAS No.	1391551-89-5
Molecular Formula	C8H8BrFNO2 • HCl
Molecular Weight	296.52 g/mol (Free base: 260.06 g/mol)
Synonyms	(2S)-2-Amino-2-(2-bromo-4-fluorophenyl)acetic acid hydrochloride; L-2-Amino-2-(2-bromo-4-fluorophenyl)acetic acid hydrochloride; (S)-2-Amino-2-(2-bromo-4-fluorophenyl)acetic acid hydrochloride; o-Bromo-p-fluoro-DL-phenylglycine hydrochloride (related to racemic mix); 2-Bromo-4-fluorophenylglycine hydrochloride; BFPG-HCl; (S)-α-Amino-(2-bromo-4-fluorophenyl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our L-2-(o-Bromo-p-Fluorophenyl)Glycine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.