Description

5-(Trifluoromethyl)-1H-Tetrazole Hydrate is a versatile heterocyclic building block characterized by its reactive tetrazole ring and trifluoromethyl substituent. This compound is highly valued in advanced organic synthesis for its role as a precursor to other functionalized tetrazoles and as a ligand in coordination chemistry. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and materials science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for compounds requiring a tetrazole moiety for bioisosteric replacement or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental persistence.
• Ligand in Catalysis: Serves as a nitrogen-donor ligand for transition metal catalysts in various cross-coupling and polymerization reactions.
• Energetic Materials Research: Investigated as a component in the formulation of high-energy-density materials (HEDMs) due to the nitrogen-rich tetrazole ring.
• Coordination Chemistry: Employed in the synthesis of metal-organic frameworks (MOFs) and other coordination polymers with potential applications in gas storage and catalysis.
• Chemical Biology Probe: Utilized in medicinal chemistry to create probes for studying enzyme inhibition and receptor binding.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Tetrazole Hydrate
CAS No.	1390655-10-3
Molecular Formula	C₂H₂F₃N₄O (Hydrate form)
Molecular Weight	152.06 g/mol (Anhydrous basis)
Synonyms	1H-Tetrazole, 5-(trifluoromethyl)-, hydrate; 5-Trifluoromethyl-1H-tetrazole monohydrate; 5-Trifluoromethyltetrazole hydrate; (Trifluoromethyl)tetrazole hydrate; Tetrazole, 5-(trifluoromethyl)-, hydrate; CF3-Tetrazole hydrate
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Tetrazole Hydrate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, water content, and impurity profiles. Our quality commitment ensures the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.