Description

4,4-Difluoro-1-[(2-Fluorophenyl)Methyl]Cyclohexane-1-Carboxylic Acid is a high-value, fluorinated organic building block characterized by its unique cyclohexane carboxylic acid core substituted with fluorine atoms and a fluorinated benzyl group. This compound matters as a critical intermediate in modern pharmaceutical and agrochemical research, enabling the synthesis of novel molecules with enhanced metabolic stability, bioavailability, and target binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel fluorinated drug candidates, including potential kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the difluoro-cyclohexyl moiety can impart improved lipophilicity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or advanced organic electronic materials due to its rigid, fluorinated structure.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships (SAR) by introducing specific steric and electronic properties into lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram quantities.
• Fluorine Chemistry Library Building: An essential component for constructing diverse chemical libraries focused on fluorine-containing compounds for high-throughput screening.

Basic Information

Product Name	4,4-Difluoro-1-[(2-Fluorophenyl)Methyl]Cyclohexane-1-Carboxylic Acid
CAS No.	1389313-48-7
Molecular Formula	C14H15F3O2
Molecular Weight	280.26 g/mol
Synonyms	1-[(2-Fluorophenyl)methyl]-4,4-difluorocyclohexane-1-carboxylic acid; 4,4-Difluoro-1-[(2-fluorobenzyl)]cyclohexanecarboxylic acid; 2-Fluorobenzyl-4,4-difluorocyclohexanecarboxylic acid; 1389313-48-7; 4,4-Difluoro-1-[(2-fluorophenyl)methyl]cyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 1-[(2-fluorophenyl)methyl]-4,4-difluoro-; 1-(2-Fluorobenzyl)-4,4-difluorocyclohexane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-[(2-Fluorophenyl)Methyl]Cyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to guarantee traceability and consistency, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.