Description

2-Methanesulfonyl-4-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both a sulfonyl and a trifluoromethyl group. This unique molecular structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where it imparts desirable properties like metabolic stability and enhanced bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the bioactivity of the trifluoromethyl and sulfonyl motifs.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where its aromatic core and functional groups modify material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to construct complex molecular architectures.

Basic Information

Product Name	2-Methanesulfonyl-4-(Trifluoromethyl)Benzonitrile
CAS No.	1383827-77-7
Molecular Formula	C9H6F3NO2S
Molecular Weight	249.21 g/mol
Synonyms	4-(Trifluoromethyl)-2-(methylsulfonyl)benzonitrile; 2-(Methylsulfonyl)-4-(trifluoromethyl)benzonitrile; 2-Methanesulfonyl-4-trifluoromethylbenzonitrile; Benzonitrile, 2-(methylsulfonyl)-4-(trifluoromethyl)-; 1383827-77-7
EINECS	Contact for details

Quality Control

Our 2-Methanesulfonyl-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.