Description

4-[3-(Benzyloxy)Phenyl]-2-Fluorobenzonitrile is a high-purity fluorinated benzonitrile derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block in organic synthesis. Its molecular structure, featuring both a benzyl-protected phenol and a fluorine-substituted nitrile group, makes it a valuable precursor for developing active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for the synthesis of novel compounds with potential therapeutic and industrial applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor for the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile synthon in cross-coupling reactions (e.g., Suzuki, Heck) and other transformations to introduce fluorinated aromatic systems.
• Academic & R&D: Employed in university and corporate research laboratories for methodological studies and the exploration of new chemical entities.
• Fluorine Chemistry: A valuable substrate for studying the effects of fluorine introduction on the physicochemical properties of organic molecules.

Basic Information

Product Name	4-[3-(Benzyloxy)Phenyl]-2-Fluorobenzonitrile
CAS No.	1381944-33-7
Molecular Formula	C20H14FNO
Molecular Weight	303.33 g/mol
Synonyms	2-Fluoro-4'-(benzyloxy)[1,1'-biphenyl]-4-carbonitrile; 4-(3-Benzyloxyphenyl)-2-fluorobenzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 2-fluoro-4'-(phenylmethoxy)-; 2-Fluoro-4'-(phenylmethoxy)[1,1'-biphenyl]-4-carbonitrile; 4-[3-(Phenylmethoxy)phenyl]-2-fluorobenzonitrile; 2-Fluoro-4'-(benzyloxy)-[1,1'-biphenyl]-4-carbonitrile; 4-(3-Benzyloxy-phenyl)-2-fluoro-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-[3-(Benzyloxy)Phenyl]-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.