Description

(Z)-2-Fluoro-5-((3-Oxoisobenzofuran-1(3H)-Ylidene)Methyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique isobenzofuranone and benzonitrile structure. This compound is critical for enabling complex synthetic pathways in modern drug discovery and development, offering researchers a precise building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorinated aromatic system can enhance biological activity and environmental stability.
• Material Science: Acts as a monomer or functional additive in the research of advanced polymers and organic electronic materials due to its conjugated system.
• Fluorine Chemistry Building Block: Provides a versatile scaffold for further fluorination or functionalization reactions in exploratory synthetic chemistry.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Dye & Pigment Intermediate: The isobenzofuranone core makes it suitable for research into novel organic dyes and fluorescent markers.

Basic Information

Product Name	(Z)-2-Fluoro-5-((3-Oxoisobenzofuran-1(3H)-Ylidene)Methyl)Benzonitrile
CAS No.	1379825-89-4
Molecular Formula	C16H8FNO2
Molecular Weight	265.24 g/mol
Synonyms	(Z)-2-Fluoro-5-[(3-oxo-1,3-dihydro-2-benzofuran-1-ylidene)methyl]benzonitrile; 2-Fluoro-5-[(Z)-(3-oxo-1,3-dihydro-2-benzofuran-1-ylidene)methyl]benzonitrile; (Z)-2-Fluoro-5-((3-oxophthalanylidene)methyl)benzonitrile; 1-(2-Cyano-4-fluorobenzylidene)-1,3-dihydro-2-benzofuran-3-one (Z-isomer); 1379825-89-4; Fluorinated Isobenzofuranone Benzonitrile; (Z)-Isomer of Fluorophthalide Benzonitrile
EINECS	Contact for details

Quality Control

Our (Z)-2-Fluoro-5-((3-Oxoisobenzofuran-1(3H)-Ylidene)Methyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isomeric integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0% (Area %)
(Z)-Isomer Content	≥ 98.0% (by HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.