Description

4-Bromo-2-Fluoro-5-Methoxy-Benzonitrile is a high-purity, multi-functional aromatic nitrile building block designed for advanced chemical synthesis. This compound is valued for its unique substitution pattern, which provides distinct reactivity and electronic properties critical for constructing complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for applications such as drug discovery and the development of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the fluorine and bromine substituents for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a core structure in the development of advanced electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig aminations.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new reaction methodologies and creating compound libraries for screening.
• Dye & Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where the methoxy and nitrile groups influence color and stability.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-Methoxy-Benzonitrile
CAS No.	1379363-37-7
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	5-Methoxy-2-fluoro-4-bromobenzonitrile; 2-Fluoro-5-methoxy-4-bromobenzonitrile; 4-Bromo-2-fluoro-5-methoxybenzonitrile; Benzonitrile, 4-bromo-2-fluoro-5-methoxy-; 1379363-37-7; 4-Br-2-F-5-MeO-BnCN
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-5-Methoxy-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP guidelines where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.