Description

2,5-Dibromo-4-Fluorobenzonitrile is a high-purity halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides multiple reactive sites for selective functionalization, making it a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as drug discovery, material science, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for bioactivity.
• Material Science Precursor: Serves as a monomer or precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to create biaryl and other complex structures.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 4-position is highly activated for substitution by various nucleophiles, enabling efficient diversification.
• Chemical Research & Development: A valuable tool for medicinal and process chemists in lead optimization and route scouting during early-stage R&D.

Basic Information

Product Name	2,5-Dibromo-4-Fluorobenzonitrile
CAS No.	1379326-67-6
Molecular Formula	C7H2Br2FN
Molecular Weight	278.90 g/mol
Synonyms	4-Fluoro-2,5-dibromobenzonitrile; 2,5-Dibromo-4-fluorobenzene carbonitrile; 2,5-Dibromo-4-fluorophenyl cyanide; Benzonitrile, 2,5-dibromo-4-fluoro-; 4-Fluoro-2,5-dibromobenzene-1-carbonitrile; 1-Cyano-2,5-dibromo-4-fluorobenzene; 2,5-Dibromo-4-fluorobenzonitrile (CAS 1379326-67-6)
EINECS	Contact for details

Quality Control

Our 2,5-Dibromo-4-Fluorobenzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.