Description

5-Fluoro-2-(Methylsulfonyl)Benzonitrile is a high-value, multi-functional chemical intermediate characterized by its unique combination of fluorine, sulfone, and nitrile functional groups. This compound matters for its critical role in modern synthetic chemistry, enabling the construction of complex molecules with tailored properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a precursor for advanced polymers and liquid crystals, where the sulfone and nitrile groups contribute to thermal stability and dielectric properties.
• Organic Synthesis Scaffold: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its versatile reactivity.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures common in many functional molecules.

Basic Information

Product Name	5-Fluoro-2-(Methylsulfonyl)Benzonitrile
CAS No.	1379097-18-3
Molecular Formula	C8H6FNO2S
Molecular Weight	199.20 g/mol
Synonyms	2-(Methylsulfonyl)-5-fluorobenzonitrile; 5-Fluoro-2-(methylsulfonyl)benzonitrile; 2-Methanesulfonyl-5-fluorobenzonitrile; 5-Fluoro-2-methanesulfonylbenzonitrile; Benzonitrile, 5-fluoro-2-(methylsulfonyl)-; 1379097-18-3; 5-Fluoro-2-methylsulfonylbenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Methylsulfonyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.