Description

5,5-Difluoropiperidine-3-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique difluorinated piperidine core, which is critical for modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel drug candidates, particularly in areas such as central nervous system (CNS) disorders and enzyme inhibition.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting protease and kinase enzymes.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the difluorinated moiety can enhance biological activity and stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and inhibitors to study biological pathways.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	5,5-Difluoropiperidine-3-Carbonitrile Hydrochloride
CAS No.	1374657-32-5
Molecular Formula	C7H9ClF2N2
Molecular Weight	194.61 g/mol
Synonyms	3-Cyano-5,5-difluoropiperidine hydrochloride; 5,5-Difluoro-3-piperidinecarbonitrile hydrochloride; 5,5-Difluoropiperidine-3-carbonitrile HCl; 5,5-Difluoro-3-cyanopiperidine hydrochloride; 3-Piperidinecarbonitrile, 5,5-difluoro-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 5,5-Difluoropiperidine-3-Carbonitrile Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each batch. Our quality system supports development under research-grade to cGMP standards, as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.