Description

4-Fluoro-5-Iodo-2-Methoxy-Benzonitrile is a high-value, multi-functional halogenated aromatic nitrile building block. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and iodine substituents for bioactivity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the synthesis of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing nitrile group and halogen atoms.
• Fluorine Chemistry & Radio-labeling Synthon: The fluorine atom provides a site for further fluorination chemistry, while the iodine is a potential handle for radio-labeling (e.g., with I-125) in diagnostic tracer development.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	4-Fluoro-5-Iodo-2-Methoxy-Benzonitrile
CAS No.	1374358-37-8
Molecular Formula	C8H5FINO
Molecular Weight	277.03 g/mol
Synonyms	2-Methoxy-4-fluoro-5-iodobenzonitrile; 4-Fluoro-5-iodo-2-methoxybenzonitrile; 5-Iodo-4-fluoro-2-methoxybenzonitrile; Benzonitrile, 4-fluoro-5-iodo-2-methoxy-; 1374358-37-8; AI3-63580; AKOS040759424; ZINC000068049749
EINECS	Contact for details

Quality Control

Our 4-Fluoro-5-Iodo-2-Methoxy-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for solvent residue analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. The compound is light-sensitive and easily oxidized; allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.