Description

4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzonitrile, 97% is a high-purity, multi-functional aromatic nitrile building block distinguished by its unique trifluoromethyl and fluorine substituents. This compound matters for its critical role in facilitating structure-activity relationship (SAR) studies and enabling the synthesis of complex molecules with tailored properties. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, as well as by material scientists exploring advanced functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and CNS-active compounds.
• Agrochemical Research: Serves as a versatile building block for synthesizing advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of fluorine atoms.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of fluorinated aromatic cores for electronic and optoelectronic materials, where the trifluoromethyl group improves stability and performance.
• Organic Synthesis & Catalysis: Acts as a substrate in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano-group transformations for constructing complex molecular architectures.
• Chemical Biology Probe Development: Employed to create tagged molecules and affinity probes for studying biological targets and pathways.

Basic Information

Item	Details
Product Name	4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzonitrile, 97%
CAS No.	1373920-92-3
Molecular Formula	C9H5F4N
Molecular Weight	203.14 g/mol
Synonyms	4-Fluoro-3-methyl-5-(trifluoromethyl)benzonitrile; 3-Methyl-4-fluoro-5-(trifluoromethyl)benzonitrile; 2-Fluoro-6-methyl-4-(trifluoromethyl)benzonitrile; 5-Cyano-2-fluoro-α,α,α-trifluoro-m-xylene; 2-Fluoro-α,α,α,6-tetramethylbenzonitrile; 1373920-92-3; FC-343 Intermediate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzonitrile, 97% undergoes rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and impurity profile. Certificates of Analysis (COA) detailing all test results are available upon request, providing full traceability and supporting your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is sensitive to strong alkali and fluoride ions; keep away from incompatible materials. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.