Description

4-Chloro-3-Ethoxy-2-Fluorobenzonitrile, 97% is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated, ethoxy, and nitrile functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine and nitrile groups for enhanced bioactivity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers or functional units for advanced polymers and liquid crystals.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or molecular probes due to its aromatic and modifiable structure.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific halogenated benzonitrile derivatives.

Basic Information

Item	Details
Product Name	4-Chloro-3-Ethoxy-2-Fluorobenzonitrile, 97%
CAS No.	1373920-89-8
Molecular Formula	C9H7ClFNO
Molecular Weight	199.61 g/mol
Synonyms	2-Fluoro-4-chloro-3-ethoxybenzonitrile; 3-Ethoxy-2-fluoro-4-chlorobenzonitrile; 4-Chloro-3-ethoxy-2-fluorobenzonitrile; 2-Fluoro-3-ethoxy-4-chlorobenzonitrile; 1373920-89-8; 4-Chloro-2-fluoro-3-ethoxybenzonitrile; Benzonitrile, 4-chloro-3-ethoxy-2-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Ethoxy-2-Fluorobenzonitrile, 97% is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the specified standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.