Description

6-Chloro-2,3-Difluorophenylacetonitrile, 97% is a high-purity, multi-functional aromatic nitrile building block essential for advanced organic synthesis. Its value lies in the strategic placement of halogen and fluorine substituents, which enable precise structural modifications and the introduction of key pharmacophores. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of novel polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Facilitates exploratory chemistry in academic institutions and corporate R&D centers for novel compound library generation.

Basic Information

Product Name	6-Chloro-2,3-Difluorophenylacetonitrile, 97%
CAS No.	1373920-84-3
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	2-(6-Chloro-2,3-difluorophenyl)acetonitrile; (6-Chloro-2,3-difluorophenyl)acetonitrile; 6-Chloro-2,3-difluorobenzeneacetonitrile; α-Chloro-2,3-difluorobenzeneacetonitrile (related); 2,3-Difluoro-6-chlorophenylacetonitrile; 1373920-84-3; Building Block C8H4ClF2N
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2,3-Difluorophenylacetonitrile undergoes rigorous analytical testing to ensure it meets the specified 97% purity grade and consistent quality. Our quality management system aligns with cGMP principles for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.