Description

4-Fluoro-3-Methyl-5-(Trifluoromethyl)Phenylacetonitrile, 97% is a high-purity, multi-fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluoro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving thermal stability and optoelectronic properties.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart chemical resistance, low surface energy, and unique dielectric properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to construct complex, fluorinated biaryl systems.
• Chemical Research & Development: A versatile building block in medicinal chemistry and discovery chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Fluoro-3-Methyl-5-(Trifluoromethyl)Phenylacetonitrile, 97%
CAS No.	1373920-75-2
Molecular Formula	C10H7F4N
Molecular Weight	217.16 g/mol
Synonyms	2-(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)acetonitrile; (4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)acetonitrile; 4-Fluoro-3-methyl-5-trifluoromethylphenylacetonitrile; 4-Fluoro-α,α,α,3-tetramethylbenzenepropanenitrile; α-(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)acetonitrile; 2-(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)ethanenitrile; CAS 1373920-75-2
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methyl-5-(Trifluoromethyl)Phenylacetonitrile, 97% is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with global regulatory and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.