Description

11,17-Difuroate Mometasone Furoate is a high-purity synthetic corticosteroid derivative, specifically a difuroate ester of mometasone. This compound is a critical advanced intermediate in the pharmaceutical synthesis of potent anti-inflammatory agents. It is primarily required by pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) manufacturers for developing and producing next-generation topical and inhalation corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of Mometasone Furoate and related high-potency corticosteroid APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel anti-inflammatory drugs.
• Process Chemistry: Serves as a reference standard and a critical starting material in scale-up and optimization of API manufacturing processes.
• Analytical Standard: Employed as a certified reference material (CRM) in HPLC, LC-MS, and NMR for quality control and method validation.
• Dermatological Formulations: Intermediate for APIs used in creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Respiratory Therapeutics: Precursor in the manufacture of APIs for nasal sprays and inhalers targeting asthma and allergic rhinitis.

Basic Information

Product Name	11,17-Difuroate Mometasone Furoate
CAS No.	1370190-33-2
Molecular Formula	C33H38Cl2O8
Molecular Weight	657.56 g/mol
Synonyms	Mometasone 11,17-Difuroate; 9,21-Dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 11,17-Bis(2-furoate); 11β,17α-Dihydroxy-16α-methyl-21-chloro-9-chloropregna-1,4-diene-3,20-dione 11,17-Difuroate; Mometasone Difuroate; 11,17-Difuroyl Mometasone; Difuroate Ester of Mometasone
EINECS	Contact for details

Quality Control

Our 11,17-Difuroate Mometasone Furoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and residual solvent screening to ensure compliance with pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.