Description

5-Chloro-3-Fluoro-2-Methylbenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chloro, fluoro, and methyl substituents on a benzonitrile core, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, substituted aromatic structure.
• Chemical Synthesis: Functions as a versatile nitrile intermediate in various organic reactions, including hydrolysis to acids, reduction to amines, and cyclization to form heterocycles.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and pigments where halogen atoms influence color fastness and spectral properties.

Basic Information

Product Name	5-Chloro-3-Fluoro-2-Methylbenzonitrile
CAS No.	1365969-38-5
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Methyl-5-chloro-3-fluorobenzonitrile; 3-Fluoro-5-chloro-2-methylbenzonitrile; Benzonitrile, 5-chloro-3-fluoro-2-methyl-; 5-Chloro-3-fluoro-o-tolunitrile; 2-Cyano-6-chloro-4-fluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-3-Fluoro-2-Methylbenzonitrile is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.