Description

2-Fluoro-1-Nitro-3-(Trifluoromethoxy)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique combination of electron-withdrawing groups, which makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, ligand synthesis, and the development of novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules containing trifluoromethoxy and nitro-substituted aromatic rings.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of advanced polymers, liquid crystals, and electronic materials that require specific fluorinated aromatic components.
• Chemical Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce complex functionalities.

Basic Information

Product Name	2-Fluoro-1-Nitro-3-(Trifluoromethoxy)Benzene
CAS No.	1365272-87-2
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	1-Fluoro-2-nitro-4-(trifluoromethoxy)benzene; 2-Fluoro-1-nitro-3-(trifluoromethoxy)benzene; 4-(Trifluoromethoxy)-2-fluoronitrobenzene; 2-Fluoro-3-(trifluoromethoxy)nitrobenzene; 2-Fluoro-α,α,α-trifluoro-3-nitrophenyl methyl ether; 3-(Trifluoromethoxy)-2-fluoronitrobenzene; Benzene, 2-fluoro-1-nitro-3-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-1-Nitro-3-(Trifluoromethoxy)Benzene undergoes rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your research and development needs. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.