Description

2-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring a unique trifluoromethyl and fluoro substitution pattern. This compound is critical for the development of advanced materials and active pharmaceutical ingredients (APIs), where its specific fluorinated structure imparts desirable properties like metabolic stability and enhanced lipophilicity. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for use in synthesis and molecular design.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used as a precursor for developing advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Liquid Crystal Materials: Serves as a core component in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Acts as an electron-transport or host material precursor in the manufacture of OLED devices.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymers, enhancing their chemical resistance and thermal stability.
• Chemical Research: A versatile building block for Suzuki, Sonogashira, and other cross-coupling reactions in medicinal and process chemistry.

Basic Information

Product Name	2-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile
CAS No.	1365272-74-7
Molecular Formula	C14H7F4N
Molecular Weight	265.21 g/mol
Synonyms	2-[4-Fluoro-3-(trifluoromethyl)phenyl]benzonitrile; [1,1'-Biphenyl]-2-carbonitrile, 4'-fluoro-3'-(trifluoromethyl)-; 4'-Fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-carbonitrile; 2-(4-Fluoro-3-trifluoromethylphenyl)benzonitrile; 2-(4-Fluoro-3-(trifluoromethyl)phenyl)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Benzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material that meets stringent in-house standards, suitable for use in cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the original container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.