Description

3-(2-Fluoro-5-Methylphenyl)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine and nitrile functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce nitrile and aryl fluoride groups into polymer backbones to alter thermal, mechanical, and chemical resistance properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive aryl fluoride moiety.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex heterocyclic systems in academic and industrial R&D settings.

Basic Information

Product Name	3-(2-Fluoro-5-Methylphenyl)Benzonitrile
CAS No.	1365272-20-3
Molecular Formula	C14H10FN
Molecular Weight	211.24 g/mol
Synonyms	2-Fluoro-5-methyl-3'-cyanobiphenyl; [1,1'-Biphenyl]-3-carbonitrile, 2'-fluoro-5'-methyl-; 3-(2-Fluoro-5-methylphenyl)benzonitrile; 2'-Fluoro-5'-methyl-[1,1'-biphenyl]-3-carbonitrile; 3-Cyano-2'-fluoro-5'-methylbiphenyl; (2-Fluoro-5-methylphenyl)benzonitrile; 3-(2-Fluoro-5-methylphenyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-(2-Fluoro-5-Methylphenyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.