Description

4-(3,5-Difluorophenyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its benzonitrile core substituted with a difluorophenyl group. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs, especially kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluorophenyl moiety can enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Chemical Research: Employed in academic and industrial R&D for cross-coupling reactions and as a scaffold for constructing complex aromatic systems.
• Fluorinated Compound Production: Acts as a versatile starting material for synthesizing other valuable fluorinated fine chemicals and building blocks.

Basic Information

Product Name	4-(3,5-Difluorophenyl)Benzonitrile
CAS No.	1365272-12-3
Molecular Formula	C13H7F2N
Molecular Weight	215.20 g/mol
Synonyms	4-(3,5-Difluorophenyl)benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 3',5'-difluoro-; 3',5'-Difluoro[1,1'-biphenyl]-4-carbonitrile; 4-(3,5-Difluorophenyl)phenyl cyanide; 3,5-Difluorobiphenyl-4-carbonitrile; 4-Cyano-3',5'-difluorobiphenyl; (3,5-Difluorophenyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-(3,5-Difluorophenyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.