Description

2-[4-(Trifluoromethoxy)Phenyl]Benzonitrile is a high-value, multi-functional aromatic nitrile derivative featuring a trifluoromethoxy substituent. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, prized for its ability to impart metabolic stability and lipophilicity to target molecules. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Active Ingredient Precursor: Used in the development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Liquid Crystal & OLED Material Synthesis: Serves as a core building block for high-performance electronic and display materials due to its aromatic and fluorinated structure.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and cyano group transformations to construct complex molecular architectures.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new reaction pathways and creating compound libraries for screening.

Basic Information

Product Name	2-[4-(Trifluoromethoxy)Phenyl]Benzonitrile
CAS No.	1365271-76-6
Molecular Formula	C14H8F3NO
Molecular Weight	263.22 g/mol
Synonyms	2-[4-(Trifluoromethoxy)phenyl]benzonitrile; [1,1'-Biphenyl]-2-carbonitrile, 4'-(trifluoromethoxy)-; 4'-(Trifluoromethoxy)[1,1'-biphenyl]-2-carbonitrile; 2-(4-Trifluoromethoxyphenyl)benzonitrile; 2-Cyano-4'-(trifluoromethoxy)biphenyl; (2-Cyanophenyl)(4-trifluoromethoxyphenyl)
EINECS	Contact for details

Quality Control

Every batch of 2-[4-(Trifluoromethoxy)Phenyl]Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.