Description

(R)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride CAS NO 1364890-61-8 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery. This compound is essential for research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the synthesis of enantiomerically pure drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a versatile building block in asymmetric catalysis and chiral pool synthesis for creating enantiomerically enriched molecules.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.

Basic Information

Product Name	(R)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	1364890-61-8
Molecular Formula	C10H12FN•HCl
Molecular Weight	201.67 g/mol (Free base: 165.21 g/mol)
Synonyms	(R)-2-(3-Fluorophenyl)pyrrolidine HCl; (R)-3-Fluoro-α-(pyrrolidin-2-yl)benzene hydrochloride; (R)-2-(3-Fluorophenyl)-1-azacyclopentane hydrochloride; (R)-2-(m-Fluorophenyl)pyrrolidine hydrochloride; (R)-NSC 781406 hydrochloride; (R)-2-(3-Fluorophenyl)pyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our (R)-2-(3-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.