Description

2-Acetyl-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a nitrile and an acetyl group on a fluorinated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its ability to coordinate with various metal centers.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials where fluorinated aromatic units are required.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Acetyl-5-Fluorobenzonitrile
CAS No.	1363508-10-4
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	5-Fluoro-2-acetylbenzonitrile; 1-(5-Fluoro-2-cyanophenyl)ethanone; 2-Acetyl-5-fluorobenzonitrile; 5-Fluoro-2-cyanophenylethanone; 2-Cyano-4-fluoroacetophenone; 4-Fluoro-2-cyanophenylethanone; Ethanone, 1-(5-fluoro-2-cyanophenyl)-
EINECS	Contact for details

Quality Control

Our 2-Acetyl-5-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.