Description

1-Bromo-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique combination of bromine, fluorine, and nitro substituents, which are critical for introducing specific reactivity and electronic properties into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-cancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups allow for selective displacement reactions to introduce a variety of nucleophiles.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine and trifluoromethyl groups on molecular properties like lipophilicity and metabolic stability.

Basic Information

Product Name	1-Bromo-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene
CAS No.	1360438-11-4
Molecular Formula	C7H2BrF4NO2
Molecular Weight	287.99 g/mol
Synonyms	2-Bromo-1-Fluoro-4-Nitro-5-(Trifluoromethyl)Benzene; 3-Bromo-2-Fluoro-6-Nitrobenzotrifluoride; 5-Bromo-4-Fluoro-2-Nitrobenzotrifluoride; 1-Bromo-2-fluoro-5-nitro-3-(trifluoromethyl)benzene; Benzene, 1-bromo-2-fluoro-5-nitro-3-(trifluoromethyl)-; 1360438-11-4
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-5-Nitro-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.