Description

3-Bromo-4-Chloro-5-Fluorobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of biological pathways and protein interactions due to its distinct spectroscopic signature.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex aryl groups.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	3-Bromo-4-Chloro-5-Fluorobenzonitrile
CAS No.	1357944-86-5
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	3-Bromo-4-chloro-5-fluorobenzonitrile; 4-Chloro-3-bromo-5-fluorobenzonitrile; 5-Fluoro-3-bromo-4-chlorobenzonitrile; Benzonitrile, 3-bromo-4-chloro-5-fluoro-; 2-Bromo-6-chloro-3-fluorobenzonitrile (regioisomer reference); BCFBN (abbreviation); 1357944-86-5 (CAS registry); 3-Br-4-Cl-5-F-C6HCN
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Chloro-5-Fluorobenzonitrile is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Any single impurity ≤1.0%; Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.