Description

4-Amino-2-Fluoro-5-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and cyano functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and anticancer agent research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Fluorine Chemistry Studies: A valuable substrate for investigating novel fluorination reactions and reaction mechanisms in academic and industrial R&D settings.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-Amino-2-Fluoro-5-Methylbenzonitrile
CAS No.	1357942-79-0
Molecular Formula	C8H7FN2
Molecular Weight	150.16 g/mol
Synonyms	2-Fluoro-5-methyl-4-aminobenzonitrile; 4-Amino-2-fluoro-5-methylbenzonitrile; 5-Methyl-2-fluoro-4-aminobenzonitrile; Benzonitrile, 4-amino-2-fluoro-5-methyl-; 4-Cyano-2-fluoro-5-methylaniline; 2-Fluoro-4-cyano-5-methylaniline; 4-Amino-2-fluoro-5-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Fluoro-5-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.