Description

(11β)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methylpregna-1,4,16-Triene-3,20-Dione CAS NO 1356190-17-4 is a high-purity synthetic steroid derivative, recognized for its role as a critical pharmaceutical intermediate. Its value lies in providing a reliable and consistent building block for the research and development of advanced therapeutic agents. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel corticosteroids and other specialized steroid-based medications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel corticosteroid drugs and other potent steroid-based therapeutics.
• Research & Development: Used in academic and industrial laboratories for pharmacological studies, structure-activity relationship (SAR) research, and metabolic pathway investigations.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scaling up synthetic routes and optimizing manufacturing processes for complex steroid molecules.
• Biochemical Research: Utilized in studies exploring steroid hormone receptor binding and modulation.

Basic Information

Product Name	(11β)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methylpregna-1,4,16-Triene-3,20-Dione
CAS No.	1356190-17-4
Molecular Formula	C22H24ClFO4
Molecular Weight	406.88 g/mol
Synonyms	21-Chloro-9-fluoro-11β,17-dihydroxy-16-methylpregna-1,4,16-triene-3,20-dione; 21-Chloro-9-fluoro-11β-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione; (11β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4,16-triene-3,20-dione; Clocortolone Impurity; Clocortolone Related Compound; Steroid Intermediate CAS 1356190-17-4
EINECS	Contact for details

Quality Control

Every batch of (11β)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methylpregna-1,4,16-Triene-3,20-Dione is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.