Description

(3R,4R,5R)-4-(Benzyloxy)-5-(Benzyloxymethyl)-3-Fluoro-Dihydrofuran-2(3H)-One is a high-purity fluorinated carbohydrate derivative and a key chiral synthon in advanced organic synthesis. This compound is valued for its precise stereochemistry and functional groups, which enable the efficient construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Antiviral Pro-drug Development: Used in the research and production of pro-drug forms of antiviral medications to enhance bioavailability and efficacy.
• Chiral Catalyst & Ligand Synthesis: Serves as a precursor for creating sophisticated chiral auxiliaries, catalysts, and ligands used in asymmetric synthesis.
• Glycochemistry Research: Employed in academic and industrial research focused on modified sugars and fluorinated carbohydrate chemistry.
• Chemical Biology Probes: Utilized to develop labeled or modified probes for studying enzymatic mechanisms and biological pathways.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(3R,4R,5R)-4-(Benzyloxy)-5-(Benzyloxymethyl)-3-Fluoro-Dihydrofuran-2(3H)-One
CAS No.	1355049-97-6
Molecular Formula	C19H19FO4
Molecular Weight	330.35 g/mol
Synonyms	(3R,4R,5R)-4-(Benzyloxy)-5-(benzyloxymethyl)-3-fluorodihydrofuran-2(3H)-one; 3-Fluoro-4,5-di-O-benzyl-2,3-dideoxy-D-erythro-pentono-1,4-lactone; 4,5-Di-O-benzyl-3-fluoro-2,3-dideoxy-D-erythro-pentono-1,4-lactone; (3R,4R,5R)-3-Fluoro-4,5-bis(benzyloxy)methyl-dihydrofuran-2-one; Fluorinated Dihydrofuranone Derivative; CAS 1355049-97-6
EINECS	Contact for details

Quality Control

Our (3R,4R,5R)-4-(Benzyloxy)-5-(Benzyloxymethyl)-3-Fluoro-Dihydrofuran-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity advanced intermediates for pharmaceutical R&D and cGMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is sensitive to strong alkali and fluorides; ensure appropriate segregation in storage. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.