Description

trans-3-Fluorocyclopentan-1-Amine is a chiral, fluorinated cyclopentylamine building block of significant interest in advanced organic synthesis. This compound matters because the strategic incorporation of fluorine and the rigid cyclopentane scaffold can dramatically alter the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where stereochemistry and fluorination are critical design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated amine moiety enhances bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The fluorinated cyclopentylamine structure is valuable for creating conformationally restricted peptide analogs and non-classical bioisosteres in medicinal chemistry.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique properties derived from the fluorine atom.
• Chemical Biology Probes: Useful for creating labeled compounds and molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	trans-3-Fluorocyclopentan-1-Amine
CAS No.	1354425-58-3
Molecular Formula	C5H10FN
Molecular Weight	103.14 g/mol
Synonyms	(1R,3S)-3-Fluorocyclopentanamine; (1S,3R)-3-Fluorocyclopentanamine; trans-3-Fluorocyclopentylamine; rel-(1R,3S)-3-Fluorocyclopentan-1-amine; 3-Fluorocyclopentanamine (trans-); 1354425-58-3; 3-Fluoro-trans-cyclopentanamine; Fluorocyclopentylamine
EINECS	Contact for details

Quality Control

Our trans-3-Fluorocyclopentan-1-Amine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.