Description

3-Fluoro-5-(Trifluoromethoxy)Benzonitrile, 97% is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethoxy substituents, makes it a valuable precursor for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and thermal stability.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and coatings, where its aromatic core and functional groups can modify polymer backbone properties.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura, Buchwald-Hartwig, and other cross-coupling reactions to create complex, multi-substituted biaryl systems.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethoxy)Benzonitrile, 97%
CAS No.	1352999-93-9
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	3-Fluoro-5-(trifluoromethoxy)benzonitrile; 5-Cyano-1-fluoro-3-(trifluoromethoxy)benzene; 1-Fluoro-3-cyano-5-(trifluoromethoxy)benzene; 3-Fluoro-5-(trifluoromethoxy)phenyl cyanide; Benzonitrile, 3-fluoro-5-(trifluoromethoxy)-; 1352999-93-9; FC6H3(OCF3)CN (meta-substituted)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethoxy)Benzonitrile, 97% is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.