Description

3-Fluoro-5-(Trifluoromethoxy)Phenylacetonitrile, 97% is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors where the introduction of fluorine and trifluoromethoxy groups is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in CNS, oncology, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorinated motifs enhance efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting materials.
• Polymer Science: Intermediate for introducing fluorinated phenyl units into specialty polymers to alter thermal and chemical resistance.
• Chemical Research: A valuable reagent for method development in cross-coupling reactions, cyano group transformations, and fluorochemistry.
• Ligand & Catalyst Development: Used to create novel fluorinated ligands for catalysis in asymmetric synthesis.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethoxy)Phenylacetonitrile, 97%
CAS No.	1352999-52-0
Molecular Formula	C9H5F4NO
Molecular Weight	219.14 g/mol
Synonyms	2-(3-Fluoro-5-(trifluoromethoxy)phenyl)acetonitrile; [3-Fluoro-5-(trifluoromethoxy)phenyl]acetonitrile; 3-Fluoro-5-(trifluoromethoxy)benzyl cyanide; α-Cyano-3-fluoro-5-(trifluoromethoxy)toluene; 2-(3-Fluoro-5-(trifluoromethoxyl)phenyl)ethanenitrile; 3-Fluoro-5-trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethoxy)Phenylacetonitrile, 97% is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency meet the specified standard. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.